Use Case Name : .../EnzymaticStimulation

For Feature : MIMEditor

Editors: DavidKane

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A user wants specify that a species is an enzyme that stimulates a reaction

Step-by-Step User Action

  1. User specifies a species to be the enzymatic stimulator
  2. User specifies a reaction to be stimulated
  3. User specifies that there is a stimulation relationship
  4. User optionally specifies the evidence for the relationship

Visual Aides

The Kohn notation for enzymatic stimulation is the following:


An example using this notation follows:


Requirements for Cytoscape

Assuming that this can use the same approach that is used for ../ShowInhibition, it could be modeled as a Hyperedge containing node1: C (hyperedge attribute: enzymatic stimulation), node2: A, node3: B

View: Use case for hyperedge view


This is of high importance, because it is very common in the maps.


When an enzyme stimulates two or more reactions, the enzyme reaction line branches and leads to enzyme reaction symbols at each target reaction.

TBD (Add a graphical example of this)

Other Examples


Shared ../MimEditorUseCaseComments

This is a special case of a ../ProcessStimulation. The enzyme binds to the complex as part of the reaction, and is unmodified after the reaction.

This could be modeled in BioPAX as a Catalysis object (e.g. Catalysis object with participants = a physicalInteraction object and a enzyme A, Controlled = the physicalInteraction object, Controller=A, Control-Type = Activation, and Direction = IRREVERSIBLE-LEFT-TO-RIGHT)

AllanKuchinsky - 2007-01-19 03:44:41

At the model level, this would be represented by ActivatingMediator nodes in HyperEdges.

Molecular_Interaction_Maps/EnzymaticStimulation (last edited 2009-02-12 01:04:15 by localhost)

Funding for Cytoscape is provided by a federal grant from the U.S. National Institute of General Medical Sciences (NIGMS) of the Na tional Institutes of Health (NIH) under award number GM070743-01. Corporate funding is provided through a contract from Unilever PLC.

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