Molecular_Interaction_Maps/EnzymaticStimulation

TableOfContents([2])

Summary

A user wants specify that a species is an enzyme that stimulates a reaction

Step-by-Step User Action

1. User specifies a species to be the enzymatic stimulator
2. User specifies a reaction to be stimulated
3. User specifies that there is a stimulation relationship
4. User optionally specifies the evidence for the relationship

Visual Aides

The Kohn notation for enzymatic stimulation is the following:

attachment:enzymaticstimulation1_061115_dwk.png

An example using this notation follows:

attachment:enzymaticstimulation2_061115_dwk.png

Requirements for Cytoscape

Assuming that this can use the same approach that is used for Inhibition, it could be modeled as a Hyperedge containing node1: C (hyperedge attribute: enzymatic stimulation), node2: A, node3: B

View: Use case for hyperedge view

Importance

This is of high importance, because it is very common in the maps.

Variations

When an enzyme stimulates two or more reactions, the enzyme reaction line branches and leads to enzyme reaction symbols at each target reaction.

TBD (Add a graphical example of this)

Other Examples

Comments

Shared MimEditorUseCaseComments

This is a special case of a ProcessStimulation. The enzyme binds to the complex as part of the reaction, and is unmodified after the reaction.

This could be modeled in BioPAX as a Catalysis object (e.g. Catalysis object with participants = a physicalInteraction object and a enzyme A, Controlled = the physicalInteraction object, Controller=A, Control-Type = Activation, and Direction = IRREVERSIBLE-LEFT-TO-RIGHT)

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