Cytoscape Wiki
Summary
A user wants specify a condition that is the combination of two previously specified conditions. The two previous conditions may exist in separate species or within the same molecule.
Step-by-Step User Action
- User specifies a species to be combined
- User specifies another species to be combined
- User specifies that the two species are to be combined
- User optionally specifies the evidence for the relationship
Visual Aides
The combination is represented with an arrowless line between the two species:
attachment:statecombination1_061117_dwk.PNG
State combinations can occur intramolecularly, for example, two different modifications on two different residues within the same molecule might be required for a specific activity. In the example below a phosphorylation reaction and an acetylation reaction are both required for stimulation:
attachment:statecombination2_061115_dwk.png
Requirements for Cytoscape
TBD
Importance
This is of moderate importance. A situation in which a reaction is contingent upon several requirements is common in biology. Examples include enzymes that need to be modified on several residues (phoshphorylation, acetylation) in order to catalyze specific reactions, or molecules that need to bind several other molecues in an unspecified order to participate in a process.
Other Examples
Comments
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