Molecular_Interaction_Maps/StateCombination

TableOfContents([2])

Summary

A user wants specify that two species are both required for a reaction, but without being bound.

Step-by-Step User Action

1. User specifies a species to be combined
2. User specifies another species to be combined
3. User specifies that the two species are to be combined
4. User optionally specifies the evidence for the relationship

Visual Aides

The combination is represented with an arrowless line between the two species:

attachment:statecombination1_061115_dwk.png

State combinations can occur intramolecularly, for example, two different modifications on two different residues within the same molecule might be required for a specific activity. In the example below a phosphorylation reaction and an acetylation reaction are both required for stimulation:

attachment:statecombination2_061115_dwk.png

Requirements for Cytoscape

TBD

Importance

A situation in which a reaction is contingent upon several requirements is common in biology. Examples include enzymes that need to be modified on several residues (phoshphorylation, acetylation) in order to catalyze specific reactions, or molecules that need to bind several other molecues in an unspecified order to participate in a process.

Other Examples

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