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Summary
A user wants to describe the possibility that protein is transported across a membrane from one compartment into another.
Step-by-Step User Action
- User specifies a species to be transported
- User specifies a starting compartment
- User specifies a destination compartment
- User optionally specifies the evidence for this relationship
Visual Aides
An example of Kohn notation for transportation:
attachment:transport1_061115_dwk.png
Requirements for Cytoscape
TBD
Importance
Being able to specify a compartment for a reaction, and to move species between compartments is critical for many maps.
Variations
Membranes are rendered with a thick double line. (See Compartment)
attachment:transport2_061115_dwk.png
If the protein is involved in reactions after being transported across the membrane, then edges for those reactions, connect to the small black dot.
attachment:transport3_061115_dwk.png
Other Examples
Comments
Shared MimEditorUseCaseComments
Some previous Kohn maps used a single line as well, but that convention does not need to be supported by the MIMEditor.
The BioPAX representation of this binding could be a Transport object, but it is not clear how to specify the compartments the species is being transported from and to.
Transport is a special case of StoichiometricConversion – converting one molecule in one Compartment to one molecule in another Compartment without net change in the number of molecules overall.