Attachment 'Sample1.xml'

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   1 <?xml version="1.0" encoding="UTF-8"?>
   2 <entrySet xmlns="net:sf:psidev:mi" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" level="2" minorVersion="3"
   3           version="5" xsi:schemaLocation="net:sf:psidev:mi http://psidev.sourceforge.net/mi/rel25/src/MIF253.xsd">
   4     <entry>
   5         <source releaseDate="2006-10-06">
   6             <names>
   7                 <shortLabel>European Bioinformatics Institute</shortLabel>
   8             </names>
   9             <bibref>
  10                 <xref>
  11                     <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference"
  12                                 refTypeAc="MI:0358"/>
  13                 </xref>
  14             </bibref>
  15             <xref>
  16                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="primary-reference" refTypeAc="MI:0358"/>
  17             </xref>
  18             <attributeList>
  19                 <attribute name="postalAddress">Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United
  20                     Kingdom
  21                 </attribute>
  22                 <attribute name="url">http://www.ebi.ac.uk</attribute>
  23             </attributeList>
  24         </source>
  25         <availabilityList/>
  26         <experimentList>
  27             <experimentDescription id="2">
  28                 <names>
  29                     <shortLabel>hobson-2001-1</shortLabel>
  30                     <fullName>Oligomeric structures of poliovirus polymerase are important for function.</fullName>
  31                 </names>
  32                 <bibref>
  33                     <xref>
  34                         <primaryRef db="pubmed" dbAc="MI:0446" id="11230138" refType="primary-reference"
  35                                     refTypeAc="MI:0358"/>
  36                     </xref>
  37                 </bibref>
  38                 <xref>
  39                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-914159" secondary="hobson-2001-1"/>
  40                 </xref>
  41                 <hostOrganismList>
  42                     <hostOrganism ncbiTaxId="-1">
  43                         <names>
  44                             <shortLabel>in vitro</shortLabel>
  45                         </names>
  46                     </hostOrganism>
  47                 </hostOrganismList>
  48                 <interactionDetectionMethod>
  49                     <names>
  50                         <shortLabel>filter binding</shortLabel>
  51                         <fullName>filter binding</fullName>
  52                         <alias>Filter overlay assay</alias>
  53                     </names>
  54                     <xref>
  55                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0049" refType="identity" refTypeAc="MI:0356"/>
  56                         <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference"
  57                                       refTypeAc="MI:0358"/>
  58                     </xref>
  59                 </interactionDetectionMethod>
  60                 <participantIdentificationMethod>
  61                     <names>
  62                         <shortLabel>predetermined</shortLabel>
  63                         <fullName>predetermined participant</fullName>
  64                     </names>
  65                     <xref>
  66                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
  67                         <secondaryRef db="pubmed" dbAc="MI:0446" id="7940758" refType="go-definition-ref"
  68                                       refTypeAc="MI:0242"/>
  69                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
  70                                       refTypeAc="MI:0358"/>
  71                     </xref>
  72                 </participantIdentificationMethod>
  73                 <attributeList>
  74                     <attribute name="author-list">Hobson SD., Rosenblum ES., Richards OC., Richmond K., Kirkegaard K.,
  75                         Schultz SC.
  76                     </attribute>
  77                     <attribute name="contact-email">scott.hobson@cellzome.de</attribute>
  78                     <attribute name="publication-year">2001</attribute>
  79                     <attribute name="exp-modification">RNA binding was evaluated using a nitrocellulose filter binding
  80                         assay. The amount of radiolabelled RNA bound to each membrane was quantified using a
  81                         PhosphorImager
  82                     </attribute>
  83                     <attribute name="journal">EMBO J. (0261-4189)</attribute>
  84                     <attribute name="data-processing">Residues renumbered to match full-length polyprotein for this
  85                         virus.
  86                     </attribute>
  87                 </attributeList>
  88             </experimentDescription>
  89             <experimentDescription id="25">
  90                 <names>
  91                     <shortLabel>hobson-2001-2</shortLabel>
  92                     <fullName>Oligomeric structures of poliovirus polymerase are important for function.</fullName>
  93                 </names>
  94                 <bibref>
  95                     <xref>
  96                         <primaryRef db="pubmed" dbAc="MI:0446" id="11230138" refType="primary-reference"
  97                                     refTypeAc="MI:0358"/>
  98                     </xref>
  99                 </bibref>
 100                 <xref>
 101                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-914232" secondary="hobson-2001-2"/>
 102                 </xref>
 103                 <hostOrganismList>
 104                     <hostOrganism ncbiTaxId="-1">
 105                         <names>
 106                             <shortLabel>in vitro</shortLabel>
 107                         </names>
 108                     </hostOrganism>
 109                 </hostOrganismList>
 110                 <interactionDetectionMethod>
 111                     <names>
 112                         <shortLabel>rna rna pol assay</shortLabel>
 113                         <fullName>rna directed rna polymerase assay</fullName>
 114                     </names>
 115                     <xref>
 116                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0700" refType="identity" refTypeAc="MI:0356"/>
 117                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 118                                       refTypeAc="MI:0358"/>
 119                     </xref>
 120                 </interactionDetectionMethod>
 121                 <participantIdentificationMethod>
 122                     <names>
 123                         <shortLabel>predetermined</shortLabel>
 124                         <fullName>predetermined participant</fullName>
 125                     </names>
 126                     <xref>
 127                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
 128                         <secondaryRef db="pubmed" dbAc="MI:0446" id="7940758" refType="go-definition-ref"
 129                                       refTypeAc="MI:0242"/>
 130                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 131                                       refTypeAc="MI:0358"/>
 132                     </xref>
 133                 </participantIdentificationMethod>
 134                 <attributeList>
 135                     <attribute name="author-list">Hobson SD., Rosenblum ES., Richards OC., Richmond K., Kirkegaard K.,
 136                         Schultz SC.
 137                     </attribute>
 138                     <attribute name="contact-email">scott.hobson@cellzome.de</attribute>
 139                     <attribute name="publication-year">2001</attribute>
 140                     <attribute name="exp-modification">Elongation assays evaluated using radiolabelled RNA as a
 141                         substrate. Elongated products were separated by PAGE and visualised using a PhosphoImager
 142                     </attribute>
 143                     <attribute name="journal">EMBO J. (0261-4189)</attribute>
 144                     <attribute name="data-processing">Residues renumbered to match full-length polyprotein for this
 145                         virus.
 146                     </attribute>
 147                 </attributeList>
 148             </experimentDescription>
 149             <experimentDescription id="41">
 150                 <names>
 151                     <shortLabel>hobson-2001-3</shortLabel>
 152                     <fullName>Oligomeric structures of poliovirus polymerase are important for function.</fullName>
 153                 </names>
 154                 <bibref>
 155                     <xref>
 156                         <primaryRef db="pubmed" dbAc="MI:0446" id="11230138" refType="primary-reference"
 157                                     refTypeAc="MI:0358"/>
 158                     </xref>
 159                 </bibref>
 160                 <xref>
 161                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-914360" secondary="hobson-2001-3"/>
 162                 </xref>
 163                 <hostOrganismList>
 164                     <hostOrganism ncbiTaxId="-1">
 165                         <names>
 166                             <shortLabel>in vitro</shortLabel>
 167                         </names>
 168                     </hostOrganism>
 169                 </hostOrganismList>
 170 
 171 
 172                 <interactionDetectionMethod>
 173                     <names>
 174                         <shortLabel>crosslink</shortLabel>
 175                         <fullName>cross-linking study</fullName>
 176                     </names>
 177                     <xref>
 178                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0030" refType="identity" refTypeAc="MI:0356"/>
 179                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 180                                       refTypeAc="MI:0358"/>
 181                     </xref>
 182                 </interactionDetectionMethod>
 183 
 184 
 185                 <participantIdentificationMethod>
 186                     <names>
 187                         <shortLabel>predetermined</shortLabel>
 188                         <fullName>predetermined participant</fullName>
 189                     </names>
 190                     <xref>
 191                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
 192                         <secondaryRef db="pubmed" dbAc="MI:0446" id="7940758" refType="go-definition-ref"
 193                                       refTypeAc="MI:0242"/>
 194                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 195                                       refTypeAc="MI:0358"/>
 196                     </xref>
 197                 </participantIdentificationMethod>
 198 
 199 
 200                 <attributeList>
 201                     <attribute name="author-list">Hobson SD., Rosenblum ES., Richards OC., Richmond K., Kirkegaard K.,
 202                         Schultz SC.
 203                     </attribute>
 204                     <attribute name="contact-email">scott.hobson@cellzome.de</attribute>
 205                     <attribute name="publication-year">2001</attribute>
 206                     <attribute name="journal">EMBO J. (0261-4189)</attribute>
 207                     <attribute name="exp-modification">2mM dithiothreotol added to reaction mixture, this was increased
 208                         to 50mM for reducing conditions. Proteins seperated by SDS-PAGE and visualised by Coomassie
 209                         staining
 210                     </attribute>
 211                     <attribute name="data-processing">Residues renumbered to match full-length polyprotein for this
 212                         virus.
 213                     </attribute>
 214                 </attributeList>
 215             </experimentDescription>
 216         </experimentList>
 217         <interactorList>
 218             <interactor id="12">
 219                 <names>
 220                     <shortLabel>ggcagcugcaugcagcugcc</shortLabel>
 221                     <fullName>5' -3' RNA synthesized for use in PMID: 11230138</fullName>
 222                 </names>
 223                 <xref>
 224                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-914168" secondary="ggcagcugcaugcagcugcc"/>
 225                 </xref>
 226                 <interactorType>
 227                     <names>
 228                         <shortLabel>rna</shortLabel>
 229                         <fullName>ribonucleic acid</fullName>
 230                         <alias>RNA</alias>
 231                     </names>
 232                     <xref>
 233                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0320" refType="identity" refTypeAc="MI:0356"/>
 234                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 235                                       refTypeAc="MI:0358"/>
 236                         <secondaryRef db="so" dbAc="MI:0601" id="SO:0000356" refType="identity" refTypeAc="MI:0356"/>
 237                     </xref>
 238                 </interactorType>
 239                 <organism ncbiTaxId="-1">
 240                     <names>
 241                         <shortLabel>in vitro</shortLabel>
 242                     </names>
 243                 </organism>
 244                 <sequence>GGCAGCUGCAUGCAGCUGCC</sequence>
 245             </interactor>
 246             <interactor id="15">
 247                 <names>
 248                     <shortLabel>ccgucgacguacgucgac-2</shortLabel>
 249                     <fullName>3'-5' RNA strand synthesised for use in PMID: 11230138</fullName>
 250                 </names>
 251                 <xref>
 252                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-944576" secondary="ccgucgacguacgucgac-2"/>
 253                 </xref>
 254                 <interactorType>
 255                     <names>
 256                         <shortLabel>rna</shortLabel>
 257                         <fullName>ribonucleic acid</fullName>
 258                         <alias>RNA</alias>
 259                     </names>
 260                     <xref>
 261                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0320" refType="identity" refTypeAc="MI:0356"/>
 262                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 263                                       refTypeAc="MI:0358"/>
 264                         <secondaryRef db="so" dbAc="MI:0601" id="SO:0000356" refType="identity" refTypeAc="MI:0356"/>
 265                     </xref>
 266                 </interactorType>
 267                 <organism ncbiTaxId="-1">
 268                     <names>
 269                         <shortLabel>in vitro</shortLabel>
 270                     </names>
 271                 </organism>
 272                 <sequence>CGUCGACGUACGUCGACGGCGCGG</sequence>
 273             </interactor>
 274             <interactor id="23">
 275                 <names>
 276                     <shortLabel>ggcgcggcagcugcaugcag</shortLabel>
 277                     <fullName>5'-3' RNA synthesized for use in PMID: 11230138</fullName>
 278                 </names>
 279                 <xref>
 280                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-914181" secondary="ggcgcggcagcugcaugcag"/>
 281                 </xref>
 282                 <interactorType>
 283                     <names>
 284                         <shortLabel>rna</shortLabel>
 285                         <fullName>ribonucleic acid</fullName>
 286                         <alias>RNA</alias>
 287                     </names>
 288                     <xref>
 289                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0320" refType="identity" refTypeAc="MI:0356"/>
 290                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 291                                       refTypeAc="MI:0358"/>
 292                         <secondaryRef db="so" dbAc="MI:0601" id="SO:0000356" refType="identity" refTypeAc="MI:0356"/>
 293                     </xref>
 294                 </interactorType>
 295                 <organism ncbiTaxId="-1">
 296                     <names>
 297                         <shortLabel>in vitro</shortLabel>
 298                     </names>
 299                 </organism>
 300                 <sequence>GGCGCGGCAGCUGCAUGCAGCUGCC</sequence>
 301             </interactor>
 302             <interactor id="27">
 303                 <names>
 304                     <shortLabel>zinc 2plus</shortLabel>
 305                     <fullName>zinc(2+)</fullName>
 306                 </names>
 307                 <xref>
 308                     <primaryRef db="chebi" dbAc="MI:0474" id="CHEBI:29105" refType="identity" refTypeAc="MI:0356"/>
 309                     <secondaryRef db="intact" dbAc="MI:0469" id="EBI-968340" secondary="zinc 2plus"/>
 310                 </xref>
 311                 <interactorType>
 312                     <names>
 313                         <shortLabel>small molecule</shortLabel>
 314                         <fullName>small molecule</fullName>
 315                     </names>
 316                     <xref>
 317                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0328" refType="identity" refTypeAc="MI:0356"/>
 318                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 319                                       refTypeAc="MI:0358"/>
 320                     </xref>
 321                 </interactorType>
 322             </interactor>
 323             <interactor id="4">
 324                 <names>
 325                     <shortLabel>ccgucgacguacgucgacgg</shortLabel>
 326                     <fullName>3' - 5' RNA strand synthesised for use in PMID: 11230138</fullName>
 327                 </names>
 328                 <xref>
 329                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-944574" secondary="ccgucgacguacgucgacgg"/>
 330                 </xref>
 331                 <interactorType>
 332                     <names>
 333                         <shortLabel>rna</shortLabel>
 334                         <fullName>ribonucleic acid</fullName>
 335                         <alias>RNA</alias>
 336                     </names>
 337                     <xref>
 338                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0320" refType="identity" refTypeAc="MI:0356"/>
 339                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 340                                       refTypeAc="MI:0358"/>
 341                         <secondaryRef db="so" dbAc="MI:0601" id="SO:0000356" refType="identity" refTypeAc="MI:0356"/>
 342                     </xref>
 343                 </interactorType>
 344                 <organism ncbiTaxId="-1">
 345                     <names>
 346                         <shortLabel>in vitro</shortLabel>
 347                     </names>
 348                 </organism>
 349                 <sequence>CCGUCGACGUACGUCGACGG</sequence>
 350             </interactor>
 351             <interactor id="6">
 352                 <names>
 353                     <shortLabel>p03300-pro_000004009</shortLabel>
 354                     <fullName>Poliovirus type 1 (strain Mahoney) RNA-directed RNA polymerase</fullName>
 355                 </names>
 356                 <xref>
 357                     <primaryRef db="uniprotkb" dbAc="MI:0486" id="P03300-PRO_0000040090" refType="identity"
 358                                 refTypeAc="MI:0356"/>
 359                     <primaryRef db="refseq" dbAc="MI:0481" id="NP_740478.2" refType="identity"
 360                                 refTypeAc="MI:0356"/>
 361                     <secondaryRef db="intact" dbAc="MI:0469" id="EBI-914162" secondary="p03300-pro_000004009"/>
 362                 </xref>
 363                 <interactorType>
 364                     <names>
 365                         <shortLabel>peptide</shortLabel>
 366                         <fullName>peptide</fullName>
 367                         <alias>oligopeptide</alias>
 368                         <alias>polypeptide</alias>
 369                     </names>
 370                     <xref>
 371                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0327" refType="identity" refTypeAc="MI:0356"/>
 372                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 373                                       refTypeAc="MI:0358"/>
 374                     </xref>
 375                 </interactorType>
 376                 <organism ncbiTaxId="12081">
 377                     <names>
 378                         <shortLabel>pol1m</shortLabel>
 379                         <fullName>Poliovirus type 1 (strain Mahoney)</fullName>
 380                     </names>
 381                 </organism>
 382                 <attributeList>
 383                     <attribute name="no-uniprot-update">An amino acid sequence which is not represented in UniProt
 384                     </attribute>
 385                 </attributeList>
 386             </interactor>
 387         </interactorList>
 388         <interactionList>
 389             <interaction id="1">
 390                 <names>
 391                     <shortLabel>polg-rna-1</shortLabel>
 392                     <fullName>Poliovirus type 1 (strain Mahoney) binds double stranded RNA</fullName>
 393                 </names>
 394                 <xref>
 395                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-914164" secondary="polg-rna-1"/>
 396                     <secondaryRef db="go" dbAc="MI:0448" id="GO:0003725" refType="function" refTypeAc="MI:0355"
 397                                   secondary="double-stranded RNA binding"/>
 398                 </xref>
 399                 <experimentList>
 400                     <experimentRef>2</experimentRef>
 401                 </experimentList>
 402                 <participantList>
 403                     <participant id="3">
 404                         <interactorRef>4</interactorRef>
 405                         <biologicalRole>
 406                             <names>
 407                                 <shortLabel>unspecified role</shortLabel>
 408                                 <fullName>unspecified role</fullName>
 409                             </names>
 410                             <xref>
 411                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity"
 412                                             refTypeAc="MI:0356"/>
 413                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 414                                               refTypeAc="MI:0358"/>
 415                             </xref>
 416                         </biologicalRole>
 417                         <experimentalRoleList>
 418                             <experimentalRole>
 419                                 <names>
 420                                     <shortLabel>prey</shortLabel>
 421                                     <fullName>prey</fullName>
 422                                 </names>
 423                                 <xref>
 424                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity"
 425                                                 refTypeAc="MI:0356"/>
 426                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 427                                                   refTypeAc="MI:0358"/>
 428                                 </xref>
 429                             </experimentalRole>
 430                         </experimentalRoleList>
 431                     </participant>
 432                     <participant id="5">
 433                         <interactorRef>6</interactorRef>
 434                         <biologicalRole>
 435                             <names>
 436                                 <shortLabel>unspecified role</shortLabel>
 437                                 <fullName>unspecified role</fullName>
 438                             </names>
 439                             <xref>
 440                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity"
 441                                             refTypeAc="MI:0356"/>
 442                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 443                                               refTypeAc="MI:0358"/>
 444                             </xref>
 445                         </biologicalRole>
 446                         <experimentalRoleList>
 447                             <experimentalRole>
 448                                 <names>
 449                                     <shortLabel>bait</shortLabel>
 450                                     <fullName>bait</fullName>
 451                                 </names>
 452                                 <xref>
 453                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity"
 454                                                 refTypeAc="MI:0356"/>
 455                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 456                                                   refTypeAc="MI:0358"/>
 457                                 </xref>
 458                             </experimentalRole>
 459                         </experimentalRoleList>
 460                         <featureList>
 461                             <feature id="7">
 462                                 <names>
 463                                     <shortLabel>leu2089ala</shortLabel>
 464                                 </names>
 465                                 <featureType>
 466                                     <names>
 467                                         <shortLabel>mutation decreasing</shortLabel>
 468                                         <fullName>mutation decreasing interaction</fullName>
 469                                         <alias>hotspot</alias>
 470                                     </names>
 471                                     <xref>
 472                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
 473                                                     refTypeAc="MI:0356"/>
 474                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 475                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 476                                     </xref>
 477                                 </featureType>
 478                                 <featureDetectionMethod>
 479                                     <names>
 480                                         <shortLabel>mutation analysis</shortLabel>
 481                                         <fullName>mutation analysis</fullName>
 482                                     </names>
 483                                     <xref>
 484                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
 485                                                     refTypeAc="MI:0356"/>
 486                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 487                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 488                                     </xref>
 489                                 </featureDetectionMethod>
 490                                 <featureRangeList>
 491                                     <featureRange>
 492                                         <startStatus>
 493                                             <names>
 494                                                 <shortLabel>certain</shortLabel>
 495                                             </names>
 496                                             <xref>
 497                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 498                                                             refTypeAc="MI:0356"/>
 499                                             </xref>
 500                                         </startStatus>
 501                                         <begin position="2089"/>
 502                                         <endStatus>
 503                                             <names>
 504                                                 <shortLabel>certain</shortLabel>
 505                                             </names>
 506                                             <xref>
 507                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 508                                                             refTypeAc="MI:0356"/>
 509                                             </xref>
 510                                         </endStatus>
 511                                         <end position="2089"/>
 512                                     </featureRange>
 513                                 </featureRangeList>
 514                             </feature>
 515                             <feature id="8">
 516                                 <names>
 517                                     <shortLabel>asp2096arg</shortLabel>
 518                                 </names>
 519                                 <featureType>
 520                                     <names>
 521                                         <shortLabel>mutation decreasing</shortLabel>
 522                                         <fullName>mutation decreasing interaction</fullName>
 523                                         <alias>hotspot</alias>
 524                                     </names>
 525                                     <xref>
 526                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
 527                                                     refTypeAc="MI:0356"/>
 528                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 529                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 530                                     </xref>
 531                                 </featureType>
 532                                 <featureDetectionMethod>
 533                                     <names>
 534                                         <shortLabel>mutation analysis</shortLabel>
 535                                         <fullName>mutation analysis</fullName>
 536                                     </names>
 537                                     <xref>
 538                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
 539                                                     refTypeAc="MI:0356"/>
 540                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 541                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 542                                     </xref>
 543                                 </featureDetectionMethod>
 544                                 <featureRangeList>
 545                                     <featureRange>
 546                                         <startStatus>
 547                                             <names>
 548                                                 <shortLabel>certain</shortLabel>
 549                                             </names>
 550                                             <xref>
 551                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 552                                                             refTypeAc="MI:0356"/>
 553                                             </xref>
 554                                         </startStatus>
 555                                         <begin position="2096"/>
 556                                         <endStatus>
 557                                             <names>
 558                                                 <shortLabel>certain</shortLabel>
 559                                             </names>
 560                                             <xref>
 561                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 562                                                             refTypeAc="MI:0356"/>
 563                                             </xref>
 564                                         </endStatus>
 565                                         <end position="2096"/>
 566                                     </featureRange>
 567                                 </featureRangeList>
 568                             </feature>
 569                             <feature id="9">
 570                                 <names>
 571                                     <shortLabel>arg2202asp</shortLabel>
 572                                 </names>
 573                                 <featureType>
 574                                     <names>
 575                                         <shortLabel>mutation decreasing</shortLabel>
 576                                         <fullName>mutation decreasing interaction</fullName>
 577                                         <alias>hotspot</alias>
 578                                     </names>
 579                                     <xref>
 580                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
 581                                                     refTypeAc="MI:0356"/>
 582                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 583                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 584                                     </xref>
 585                                 </featureType>
 586                                 <featureDetectionMethod>
 587                                     <names>
 588                                         <shortLabel>mutation analysis</shortLabel>
 589                                         <fullName>mutation analysis</fullName>
 590                                     </names>
 591                                     <xref>
 592                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
 593                                                     refTypeAc="MI:0356"/>
 594                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 595                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 596                                     </xref>
 597                                 </featureDetectionMethod>
 598                                 <featureRangeList>
 599                                     <featureRange>
 600                                         <startStatus>
 601                                             <names>
 602                                                 <shortLabel>certain</shortLabel>
 603                                             </names>
 604                                             <xref>
 605                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 606                                                             refTypeAc="MI:0356"/>
 607                                             </xref>
 608                                         </startStatus>
 609                                         <begin position="2202"/>
 610                                         <endStatus>
 611                                             <names>
 612                                                 <shortLabel>certain</shortLabel>
 613                                             </names>
 614                                             <xref>
 615                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 616                                                             refTypeAc="MI:0356"/>
 617                                             </xref>
 618                                         </endStatus>
 619                                         <end position="2202"/>
 620                                     </featureRange>
 621                                 </featureRangeList>
 622                             </feature>
 623                             <feature id="10">
 624                                 <names>
 625                                     <shortLabel>arg2203asp</shortLabel>
 626                                 </names>
 627                                 <featureType>
 628                                     <names>
 629                                         <shortLabel>mutation decreasing</shortLabel>
 630                                         <fullName>mutation decreasing interaction</fullName>
 631                                         <alias>hotspot</alias>
 632                                     </names>
 633                                     <xref>
 634                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
 635                                                     refTypeAc="MI:0356"/>
 636                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 637                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 638                                     </xref>
 639                                 </featureType>
 640                                 <featureDetectionMethod>
 641                                     <names>
 642                                         <shortLabel>mutation analysis</shortLabel>
 643                                         <fullName>mutation analysis</fullName>
 644                                     </names>
 645                                     <xref>
 646                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
 647                                                     refTypeAc="MI:0356"/>
 648                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 649                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 650                                     </xref>
 651                                 </featureDetectionMethod>
 652                                 <featureRangeList>
 653                                     <featureRange>
 654                                         <startStatus>
 655                                             <names>
 656                                                 <shortLabel>certain</shortLabel>
 657                                             </names>
 658                                             <xref>
 659                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 660                                                             refTypeAc="MI:0356"/>
 661                                             </xref>
 662                                         </startStatus>
 663                                         <begin position="2203"/>
 664                                         <endStatus>
 665                                             <names>
 666                                                 <shortLabel>certain</shortLabel>
 667                                             </names>
 668                                             <xref>
 669                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 670                                                             refTypeAc="MI:0356"/>
 671                                             </xref>
 672                                         </endStatus>
 673                                         <end position="2203"/>
 674                                     </featureRange>
 675                                 </featureRangeList>
 676                             </feature>
 677                         </featureList>
 678                         <hostOrganismList>
 679                             <hostOrganism ncbiTaxId="12081">
 680                                 <names>
 681                                     <shortLabel>pol1m</shortLabel>
 682                                     <fullName>Poliovirus type 1 (strain Mahoney)</fullName>
 683                                 </names>
 684                             </hostOrganism>
 685                         </hostOrganismList>
 686                     </participant>
 687                     <participant id="11">
 688                         <interactorRef>12</interactorRef>
 689                         <biologicalRole>
 690                             <names>
 691                                 <shortLabel>unspecified role</shortLabel>
 692                                 <fullName>unspecified role</fullName>
 693                             </names>
 694                             <xref>
 695                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity"
 696                                             refTypeAc="MI:0356"/>
 697                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 698                                               refTypeAc="MI:0358"/>
 699                             </xref>
 700                         </biologicalRole>
 701                         <experimentalRoleList>
 702                             <experimentalRole>
 703                                 <names>
 704                                     <shortLabel>prey</shortLabel>
 705                                     <fullName>prey</fullName>
 706                                 </names>
 707                                 <xref>
 708                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity"
 709                                                 refTypeAc="MI:0356"/>
 710                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 711                                                   refTypeAc="MI:0358"/>
 712                                 </xref>
 713                             </experimentalRole>
 714                         </experimentalRoleList>
 715                     </participant>
 716                 </participantList>
 717                 <interactionType>
 718                     <names>
 719                         <shortLabel>direct interaction</shortLabel>
 720                         <fullName>direct interaction</fullName>
 721                     </names>
 722                     <xref>
 723                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
 724                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 725                                       refTypeAc="MI:0358"/>
 726                     </xref>
 727                 </interactionType>
 728                 <attributeList>
 729                     <attribute name="kinetics">ED50 (wild-type)=3x10exp-6M</attribute>
 730                     <attribute name="comment">RNA strands bind to form a blunt ended double strand, authors name 0.20
 731                         RNA
 732                     </attribute>
 733                     <attribute name="figure legend">2A, 2C</attribute>
 734                     <attribute name="comment">Protein bound single stranded RNA's with approximately 10 fold lower
 735                         affinity.
 736                     </attribute>
 737                     <attribute name="kd">0.0</attribute>
 738                 </attributeList>
 739             </interaction>
 740             <interaction id="13">
 741                 <names>
 742                     <shortLabel>polg-rna-2</shortLabel>
 743                     <fullName>Poliovirus type 1 (strain Mahoney) binds double stranded RNA</fullName>
 744                 </names>
 745                 <xref>
 746                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-914187" secondary="polg-rna-2"/>
 747                     <secondaryRef db="go" dbAc="MI:0448" id="GO:0003725" refType="function" refTypeAc="MI:0355"
 748                                   secondary="double-stranded RNA binding"/>
 749                 </xref>
 750                 <experimentList>
 751                     <experimentRef>2</experimentRef>
 752                 </experimentList>
 753                 <participantList>
 754                     <participant id="14">
 755                         <interactorRef>15</interactorRef>
 756                         <biologicalRole>
 757                             <names>
 758                                 <shortLabel>unspecified role</shortLabel>
 759                                 <fullName>unspecified role</fullName>
 760                             </names>
 761                             <xref>
 762                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity"
 763                                             refTypeAc="MI:0356"/>
 764                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 765                                               refTypeAc="MI:0358"/>
 766                             </xref>
 767                         </biologicalRole>
 768                         <experimentalRoleList>
 769                             <experimentalRole>
 770                                 <names>
 771                                     <shortLabel>prey</shortLabel>
 772                                     <fullName>prey</fullName>
 773                                 </names>
 774                                 <xref>
 775                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity"
 776                                                 refTypeAc="MI:0356"/>
 777                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 778                                                   refTypeAc="MI:0358"/>
 779                                 </xref>
 780                             </experimentalRole>
 781                         </experimentalRoleList>
 782                     </participant>
 783                     <participant id="16">
 784                         <interactorRef>6</interactorRef>
 785                         <biologicalRole>
 786                             <names>
 787                                 <shortLabel>unspecified role</shortLabel>
 788                                 <fullName>unspecified role</fullName>
 789                             </names>
 790                             <xref>
 791                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity"
 792                                             refTypeAc="MI:0356"/>
 793                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 794                                               refTypeAc="MI:0358"/>
 795                             </xref>
 796                         </biologicalRole>
 797                         <experimentalRoleList>
 798                             <experimentalRole>
 799                                 <names>
 800                                     <shortLabel>bait</shortLabel>
 801                                     <fullName>bait</fullName>
 802                                 </names>
 803                                 <xref>
 804                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity"
 805                                                 refTypeAc="MI:0356"/>
 806                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
 807                                                   refTypeAc="MI:0358"/>
 808                                 </xref>
 809                             </experimentalRole>
 810                         </experimentalRoleList>
 811                         <featureList>
 812                             <feature id="17">
 813                                 <names>
 814                                     <shortLabel>region</shortLabel>
 815                                 </names>
 816                                 <featureType>
 817                                     <names>
 818                                         <shortLabel>sufficient to bind</shortLabel>
 819                                         <fullName>sufficient binding site</fullName>
 820                                     </names>
 821                                     <xref>
 822                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0442" refType="identity"
 823                                                     refTypeAc="MI:0356"/>
 824                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 825                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 826                                     </xref>
 827                                 </featureType>
 828                                 <featureRangeList>
 829                                     <featureRange>
 830                                         <startStatus>
 831                                             <names>
 832                                                 <shortLabel>certain</shortLabel>
 833                                             </names>
 834                                             <xref>
 835                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 836                                                             refTypeAc="MI:0356"/>
 837                                             </xref>
 838                                         </startStatus>
 839                                         <begin position="1812"/>
 840                                         <endStatus>
 841                                             <names>
 842                                                 <shortLabel>certain</shortLabel>
 843                                             </names>
 844                                             <xref>
 845                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 846                                                             refTypeAc="MI:0356"/>
 847                                             </xref>
 848                                         </endStatus>
 849                                         <end position="2208"/>
 850                                     </featureRange>
 851                                 </featureRangeList>
 852                             </feature>
 853                             <feature id="18">
 854                                 <names>
 855                                     <shortLabel>asp2096arg</shortLabel>
 856                                 </names>
 857                                 <featureType>
 858                                     <names>
 859                                         <shortLabel>mutation decreasing</shortLabel>
 860                                         <fullName>mutation decreasing interaction</fullName>
 861                                         <alias>hotspot</alias>
 862                                     </names>
 863                                     <xref>
 864                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
 865                                                     refTypeAc="MI:0356"/>
 866                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 867                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 868                                     </xref>
 869                                 </featureType>
 870                                 <featureDetectionMethod>
 871                                     <names>
 872                                         <shortLabel>mutation analysis</shortLabel>
 873                                         <fullName>mutation analysis</fullName>
 874                                     </names>
 875                                     <xref>
 876                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
 877                                                     refTypeAc="MI:0356"/>
 878                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 879                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 880                                     </xref>
 881                                 </featureDetectionMethod>
 882                                 <featureRangeList>
 883                                     <featureRange>
 884                                         <startStatus>
 885                                             <names>
 886                                                 <shortLabel>certain</shortLabel>
 887                                             </names>
 888                                             <xref>
 889                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 890                                                             refTypeAc="MI:0356"/>
 891                                             </xref>
 892                                         </startStatus>
 893                                         <begin position="2096"/>
 894                                         <endStatus>
 895                                             <names>
 896                                                 <shortLabel>certain</shortLabel>
 897                                             </names>
 898                                             <xref>
 899                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 900                                                             refTypeAc="MI:0356"/>
 901                                             </xref>
 902                                         </endStatus>
 903                                         <end position="2096"/>
 904                                     </featureRange>
 905                                 </featureRangeList>
 906                             </feature>
 907                             <feature id="19">
 908                                 <names>
 909                                     <shortLabel>arg2202asp</shortLabel>
 910                                 </names>
 911                                 <featureType>
 912                                     <names>
 913                                         <shortLabel>mutation decreasing</shortLabel>
 914                                         <fullName>mutation decreasing interaction</fullName>
 915                                         <alias>hotspot</alias>
 916                                     </names>
 917                                     <xref>
 918                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
 919                                                     refTypeAc="MI:0356"/>
 920                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 921                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 922                                     </xref>
 923                                 </featureType>
 924                                 <featureDetectionMethod>
 925                                     <names>
 926                                         <shortLabel>mutation analysis</shortLabel>
 927                                         <fullName>mutation analysis</fullName>
 928                                     </names>
 929                                     <xref>
 930                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
 931                                                     refTypeAc="MI:0356"/>
 932                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 933                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 934                                     </xref>
 935                                 </featureDetectionMethod>
 936                                 <featureRangeList>
 937                                     <featureRange>
 938                                         <startStatus>
 939                                             <names>
 940                                                 <shortLabel>certain</shortLabel>
 941                                             </names>
 942                                             <xref>
 943                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 944                                                             refTypeAc="MI:0356"/>
 945                                             </xref>
 946                                         </startStatus>
 947                                         <begin position="2202"/>
 948                                         <endStatus>
 949                                             <names>
 950                                                 <shortLabel>certain</shortLabel>
 951                                             </names>
 952                                             <xref>
 953                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 954                                                             refTypeAc="MI:0356"/>
 955                                             </xref>
 956                                         </endStatus>
 957                                         <end position="2202"/>
 958                                     </featureRange>
 959                                 </featureRangeList>
 960                             </feature>
 961                             <feature id="20">
 962                                 <names>
 963                                     <shortLabel>arg2203asp</shortLabel>
 964                                 </names>
 965                                 <featureType>
 966                                     <names>
 967                                         <shortLabel>mutation decreasing</shortLabel>
 968                                         <fullName>mutation decreasing interaction</fullName>
 969                                         <alias>hotspot</alias>
 970                                     </names>
 971                                     <xref>
 972                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
 973                                                     refTypeAc="MI:0356"/>
 974                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 975                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 976                                     </xref>
 977                                 </featureType>
 978                                 <featureDetectionMethod>
 979                                     <names>
 980                                         <shortLabel>mutation analysis</shortLabel>
 981                                         <fullName>mutation analysis</fullName>
 982                                     </names>
 983                                     <xref>
 984                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
 985                                                     refTypeAc="MI:0356"/>
 986                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
 987                                                       refType="primary-reference" refTypeAc="MI:0358"/>
 988                                     </xref>
 989                                 </featureDetectionMethod>
 990                                 <featureRangeList>
 991                                     <featureRange>
 992                                         <startStatus>
 993                                             <names>
 994                                                 <shortLabel>certain</shortLabel>
 995                                             </names>
 996                                             <xref>
 997                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
 998                                                             refTypeAc="MI:0356"/>
 999                                             </xref>
1000                                         </startStatus>
1001                                         <begin position="2203"/>
1002                                         <endStatus>
1003                                             <names>
1004                                                 <shortLabel>certain</shortLabel>
1005                                             </names>
1006                                             <xref>
1007                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1008                                                             refTypeAc="MI:0356"/>
1009                                             </xref>
1010                                         </endStatus>
1011                                         <end position="2203"/>
1012                                     </featureRange>
1013                                 </featureRangeList>
1014                             </feature>
1015                             <feature id="21">
1016                                 <names>
1017                                     <shortLabel>leu2089ala</shortLabel>
1018                                 </names>
1019                                 <featureType>
1020                                     <names>
1021                                         <shortLabel>mutation decreasing</shortLabel>
1022                                         <fullName>mutation decreasing interaction</fullName>
1023                                         <alias>hotspot</alias>
1024                                     </names>
1025                                     <xref>
1026                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
1027                                                     refTypeAc="MI:0356"/>
1028                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1029                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1030                                     </xref>
1031                                 </featureType>
1032                                 <featureDetectionMethod>
1033                                     <names>
1034                                         <shortLabel>mutation analysis</shortLabel>
1035                                         <fullName>mutation analysis</fullName>
1036                                     </names>
1037                                     <xref>
1038                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1039                                                     refTypeAc="MI:0356"/>
1040                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1041                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1042                                     </xref>
1043                                 </featureDetectionMethod>
1044                                 <featureRangeList>
1045                                     <featureRange>
1046                                         <startStatus>
1047                                             <names>
1048                                                 <shortLabel>certain</shortLabel>
1049                                             </names>
1050                                             <xref>
1051                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1052                                                             refTypeAc="MI:0356"/>
1053                                             </xref>
1054                                         </startStatus>
1055                                         <begin position="2089"/>
1056                                         <endStatus>
1057                                             <names>
1058                                                 <shortLabel>certain</shortLabel>
1059                                             </names>
1060                                             <xref>
1061                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1062                                                             refTypeAc="MI:0356"/>
1063                                             </xref>
1064                                         </endStatus>
1065                                         <end position="2089"/>
1066                                     </featureRange>
1067                                 </featureRangeList>
1068                             </feature>
1069                         </featureList>
1070                         <hostOrganismList>
1071                             <hostOrganism ncbiTaxId="12081">
1072                                 <names>
1073                                     <shortLabel>pol1m</shortLabel>
1074                                     <fullName>Poliovirus type 1 (strain Mahoney)</fullName>
1075                                 </names>
1076                             </hostOrganism>
1077                         </hostOrganismList>
1078                     </participant>
1079                     <participant id="22">
1080                         <interactorRef>23</interactorRef>
1081                         <biologicalRole>
1082                             <names>
1083                                 <shortLabel>unspecified role</shortLabel>
1084                                 <fullName>unspecified role</fullName>
1085                             </names>
1086                             <xref>
1087                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity"
1088                                             refTypeAc="MI:0356"/>
1089                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1090                                               refTypeAc="MI:0358"/>
1091                             </xref>
1092                         </biologicalRole>
1093                         <experimentalRoleList>
1094                             <experimentalRole>
1095                                 <names>
1096                                     <shortLabel>prey</shortLabel>
1097                                     <fullName>prey</fullName>
1098                                 </names>
1099                                 <xref>
1100                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity"
1101                                                 refTypeAc="MI:0356"/>
1102                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1103                                                   refTypeAc="MI:0358"/>
1104                                 </xref>
1105                             </experimentalRole>
1106                         </experimentalRoleList>
1107                     </participant>
1108                 </participantList>
1109                 <interactionType>
1110                     <names>
1111                         <shortLabel>direct interaction</shortLabel>
1112                         <fullName>direct interaction</fullName>
1113                     </names>
1114                     <xref>
1115                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
1116                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1117                                       refTypeAc="MI:0358"/>
1118                     </xref>
1119                 </interactionType>
1120                 <attributeList>
1121                     <attribute name="kinetics">ED50 (wild-type)=6x10exp-6M</attribute>
1122                     <attribute name="comment">RNA strands bind to form a blunt ended double strand, authors name 5.20
1123                         RNA
1124                     </attribute>
1125                     <attribute name="figure legend">2A, 2D</attribute>
1126                     <attribute name="comment">Protein bound single stranded RNA's with approximately 10 fold lower
1127                         affinity.
1128                     </attribute>
1129                     <attribute name="kd">0.0</attribute>
1130                 </attributeList>
1131             </interaction>
1132             <interaction id="24">
1133                 <names>
1134                     <shortLabel>polg-rna-3</shortLabel>
1135                     <fullName>Poliovirus type 1 (strain Mahoney) binds double stranded RNA</fullName>
1136                 </names>
1137                 <xref>
1138                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-914242" secondary="polg-rna-3"/>
1139                     <secondaryRef db="go" dbAc="MI:0448" id="GO:0003725" refType="function" refTypeAc="MI:0355"
1140                                   secondary="double-stranded RNA binding"/>
1141                     <secondaryRef db="go" dbAc="MI:0448" id="GO:0003968" refType="function" refTypeAc="MI:0355"
1142                                   secondary="RNA-directed RNA polymerase ac"/>
1143                     <secondaryRef db="go" dbAc="MI:0448" id="GO:0006354" refType="process" refTypeAc="MI:0359"
1144                                   secondary="RNA elongation"/>
1145                     <secondaryRef db="go" dbAc="MI:0448" id="GO:0008270" refType="function" refTypeAc="MI:0355"
1146                                   secondary="zinc ion binding"/>
1147                 </xref>
1148                 <experimentList>
1149                     <experimentRef>25</experimentRef>
1150                 </experimentList>
1151                 <participantList>
1152                     <participant id="26">
1153                         <interactorRef>27</interactorRef>
1154                         <biologicalRole>
1155                             <names>
1156                                 <shortLabel>cofactor</shortLabel>
1157                                 <fullName>cofactor</fullName>
1158                                 <alias>coenzyme</alias>
1159                             </names>
1160                             <xref>
1161                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0682" refType="identity"
1162                                             refTypeAc="MI:0356"/>
1163                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1164                                               refTypeAc="MI:0358"/>
1165                             </xref>
1166                         </biologicalRole>
1167                         <experimentalRoleList>
1168                             <experimentalRole>
1169                                 <names>
1170                                     <shortLabel>cofactor</shortLabel>
1171                                     <fullName>cofactor</fullName>
1172                                     <alias>coenzyme</alias>
1173                                 </names>
1174                                 <xref>
1175                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0682" refType="identity"
1176                                                 refTypeAc="MI:0356"/>
1177                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1178                                                   refTypeAc="MI:0358"/>
1179                                 </xref>
1180                             </experimentalRole>
1181                         </experimentalRoleList>
1182                     </participant>
1183                     <participant id="28">
1184                         <interactorRef>15</interactorRef>
1185                         <biologicalRole>
1186                             <names>
1187                                 <shortLabel>enzyme target</shortLabel>
1188                                 <fullName>enzyme target</fullName>
1189                                 <alias>substrate</alias>
1190                             </names>
1191                             <xref>
1192                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0502" refType="identity"
1193                                             refTypeAc="MI:0356"/>
1194                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1195                                               refTypeAc="MI:0358"/>
1196                             </xref>
1197                         </biologicalRole>
1198                         <experimentalRoleList>
1199                             <experimentalRole>
1200                                 <names>
1201                                     <shortLabel>neutral component</shortLabel>
1202                                     <fullName>neutral component</fullName>
1203                                 </names>
1204                                 <xref>
1205                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity"
1206                                                 refTypeAc="MI:0356"/>
1207                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1208                                                   refTypeAc="MI:0358"/>
1209                                 </xref>
1210                             </experimentalRole>
1211                         </experimentalRoleList>
1212                     </participant>
1213                     <participant id="29">
1214                         <interactorRef>6</interactorRef>
1215                         <biologicalRole>
1216                             <names>
1217                                 <shortLabel>enzyme</shortLabel>
1218                                 <fullName>enzyme</fullName>
1219                             </names>
1220                             <xref>
1221                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0501" refType="identity"
1222                                             refTypeAc="MI:0356"/>
1223                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1224                                               refTypeAc="MI:0358"/>
1225                             </xref>
1226                         </biologicalRole>
1227                         <experimentalRoleList>
1228                             <experimentalRole>
1229                                 <names>
1230                                     <shortLabel>neutral component</shortLabel>
1231                                     <fullName>neutral component</fullName>
1232                                 </names>
1233                                 <xref>
1234                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity"
1235                                                 refTypeAc="MI:0356"/>
1236                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1237                                                   refTypeAc="MI:0358"/>
1238                                 </xref>
1239                             </experimentalRole>
1240                         </experimentalRoleList>
1241                         <featureList>
1242                             <feature id="30">
1243                                 <names>
1244                                     <shortLabel>region</shortLabel>
1245                                 </names>
1246                                 <featureType>
1247                                     <names>
1248                                         <shortLabel>required to bind</shortLabel>
1249                                         <fullName>necessary binding site</fullName>
1250                                     </names>
1251                                     <xref>
1252                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0429" refType="identity"
1253                                                     refTypeAc="MI:0356"/>
1254                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1255                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1256                                     </xref>
1257                                 </featureType>
1258                                 <featureDetectionMethod>
1259                                     <names>
1260                                         <shortLabel>deletion analysis</shortLabel>
1261                                         <fullName>deletion analysis</fullName>
1262                                     </names>
1263                                     <xref>
1264                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0033" refType="identity"
1265                                                     refTypeAc="MI:0356"/>
1266                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1267                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1268                                     </xref>
1269                                 </featureDetectionMethod>
1270                                 <featureRangeList>
1271                                     <featureRange>
1272                                         <startStatus>
1273                                             <names>
1274                                                 <shortLabel>certain</shortLabel>
1275                                             </names>
1276                                             <xref>
1277                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1278                                                             refTypeAc="MI:0356"/>
1279                                             </xref>
1280                                         </startStatus>
1281                                         <begin position="1747"/>
1282                                         <endStatus>
1283                                             <names>
1284                                                 <shortLabel>certain</shortLabel>
1285                                             </names>
1286                                             <xref>
1287                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1288                                                             refTypeAc="MI:0356"/>
1289                                             </xref>
1290                                         </endStatus>
1291                                         <end position="1812"/>
1292                                     </featureRange>
1293                                 </featureRangeList>
1294                             </feature>
1295                             <feature id="31">
1296                                 <names>
1297                                     <shortLabel>ala1776cys</shortLabel>
1298                                 </names>
1299                                 <featureType>
1300                                     <names>
1301                                         <shortLabel>mutation decreasing</shortLabel>
1302                                         <fullName>mutation decreasing interaction</fullName>
1303                                         <alias>hotspot</alias>
1304                                     </names>
1305                                     <xref>
1306                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
1307                                                     refTypeAc="MI:0356"/>
1308                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1309                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1310                                     </xref>
1311                                 </featureType>
1312                                 <featureDetectionMethod>
1313                                     <names>
1314                                         <shortLabel>mutation analysis</shortLabel>
1315                                         <fullName>mutation analysis</fullName>
1316                                     </names>
1317                                     <xref>
1318                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1319                                                     refTypeAc="MI:0356"/>
1320                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1321                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1322                                     </xref>
1323                                 </featureDetectionMethod>
1324                                 <featureRangeList>
1325                                     <featureRange>
1326                                         <startStatus>
1327                                             <names>
1328                                                 <shortLabel>certain</shortLabel>
1329                                             </names>
1330                                             <xref>
1331                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1332                                                             refTypeAc="MI:0356"/>
1333                                             </xref>
1334                                         </startStatus>
1335                                         <begin position="1776"/>
1336                                         <endStatus>
1337                                             <names>
1338                                                 <shortLabel>certain</shortLabel>
1339                                             </names>
1340                                             <xref>
1341                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1342                                                             refTypeAc="MI:0356"/>
1343                                             </xref>
1344                                         </endStatus>
1345                                         <end position="1776"/>
1346                                     </featureRange>
1347                                 </featureRangeList>
1348                             </feature>
1349                             <feature id="32">
1350                                 <names>
1351                                     <shortLabel>region</shortLabel>
1352                                 </names>
1353                                 <featureType>
1354                                     <names>
1355                                         <shortLabel>mutation decreasing</shortLabel>
1356                                         <fullName>mutation decreasing interaction</fullName>
1357                                         <alias>hotspot</alias>
1358                                     </names>
1359                                     <xref>
1360                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
1361                                                     refTypeAc="MI:0356"/>
1362                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1363                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1364                                     </xref>
1365                                 </featureType>
1366                                 <featureDetectionMethod>
1367                                     <names>
1368                                         <shortLabel>mutation analysis</shortLabel>
1369                                         <fullName>mutation analysis</fullName>
1370                                     </names>
1371                                     <xref>
1372                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1373                                                     refTypeAc="MI:0356"/>
1374                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1375                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1376                                     </xref>
1377                                 </featureDetectionMethod>
1378                                 <featureRangeList>
1379                                     <featureRange>
1380                                         <startStatus>
1381                                             <names>
1382                                                 <shortLabel>certain</shortLabel>
1383                                             </names>
1384                                             <xref>
1385                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1386                                                             refTypeAc="MI:0356"/>
1387                                             </xref>
1388                                         </startStatus>
1389                                         <begin position="1777"/>
1390                                         <endStatus>
1391                                             <names>
1392                                                 <shortLabel>certain</shortLabel>
1393                                             </names>
1394                                             <xref>
1395                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1396                                                             refTypeAc="MI:0356"/>
1397                                             </xref>
1398                                         </endStatus>
1399                                         <end position="1777"/>
1400                                     </featureRange>
1401                                 </featureRangeList>
1402                             </feature>
1403                             <feature id="33">
1404                                 <names>
1405                                     <shortLabel>iso2188cys</shortLabel>
1406                                 </names>
1407                                 <featureType>
1408                                     <names>
1409                                         <shortLabel>mutation decreasing</shortLabel>
1410                                         <fullName>mutation decreasing interaction</fullName>
1411                                         <alias>hotspot</alias>
1412                                     </names>
1413                                     <xref>
1414                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
1415                                                     refTypeAc="MI:0356"/>
1416                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1417                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1418                                     </xref>
1419                                 </featureType>
1420                                 <featureDetectionMethod>
1421                                     <names>
1422                                         <shortLabel>mutation analysis</shortLabel>
1423                                         <fullName>mutation analysis</fullName>
1424                                     </names>
1425                                     <xref>
1426                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1427                                                     refTypeAc="MI:0356"/>
1428                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1429                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1430                                     </xref>
1431                                 </featureDetectionMethod>
1432                                 <featureRangeList>
1433                                     <featureRange>
1434                                         <startStatus>
1435                                             <names>
1436                                                 <shortLabel>certain</shortLabel>
1437                                             </names>
1438                                             <xref>
1439                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1440                                                             refTypeAc="MI:0356"/>
1441                                             </xref>
1442                                         </startStatus>
1443                                         <begin position="2188"/>
1444                                         <endStatus>
1445                                             <names>
1446                                                 <shortLabel>certain</shortLabel>
1447                                             </names>
1448                                             <xref>
1449                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1450                                                             refTypeAc="MI:0356"/>
1451                                             </xref>
1452                                         </endStatus>
1453                                         <end position="2188"/>
1454                                     </featureRange>
1455                                 </featureRangeList>
1456                             </feature>
1457                             <feature id="34">
1458                                 <names>
1459                                     <shortLabel>gly2189leu</shortLabel>
1460                                 </names>
1461                                 <featureType>
1462                                     <names>
1463                                         <shortLabel>mutation decreasing</shortLabel>
1464                                         <fullName>mutation decreasing interaction</fullName>
1465                                         <alias>hotspot</alias>
1466                                     </names>
1467                                     <xref>
1468                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
1469                                                     refTypeAc="MI:0356"/>
1470                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1471                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1472                                     </xref>
1473                                 </featureType>
1474                                 <featureDetectionMethod>
1475                                     <names>
1476                                         <shortLabel>mutation analysis</shortLabel>
1477                                         <fullName>mutation analysis</fullName>
1478                                     </names>
1479                                     <xref>
1480                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1481                                                     refTypeAc="MI:0356"/>
1482                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1483                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1484                                     </xref>
1485                                 </featureDetectionMethod>
1486                                 <featureRangeList>
1487                                     <featureRange>
1488                                         <startStatus>
1489                                             <names>
1490                                                 <shortLabel>certain</shortLabel>
1491                                             </names>
1492                                             <xref>
1493                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1494                                                             refTypeAc="MI:0356"/>
1495                                             </xref>
1496                                         </startStatus>
1497                                         <begin position="2189"/>
1498                                         <endStatus>
1499                                             <names>
1500                                                 <shortLabel>certain</shortLabel>
1501                                             </names>
1502                                             <xref>
1503                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1504                                                             refTypeAc="MI:0356"/>
1505                                             </xref>
1506                                         </endStatus>
1507                                         <end position="2189"/>
1508                                     </featureRange>
1509                                 </featureRangeList>
1510                             </feature>
1511                             <feature id="35">
1512                                 <names>
1513                                     <shortLabel>asp2096arg</shortLabel>
1514                                 </names>
1515                                 <featureType>
1516                                     <names>
1517                                         <shortLabel>mutation decreasing</shortLabel>
1518                                         <fullName>mutation decreasing interaction</fullName>
1519                                         <alias>hotspot</alias>
1520                                     </names>
1521                                     <xref>
1522                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
1523                                                     refTypeAc="MI:0356"/>
1524                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1525                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1526                                     </xref>
1527                                 </featureType>
1528                                 <featureDetectionMethod>
1529                                     <names>
1530                                         <shortLabel>mutation analysis</shortLabel>
1531                                         <fullName>mutation analysis</fullName>
1532                                     </names>
1533                                     <xref>
1534                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1535                                                     refTypeAc="MI:0356"/>
1536                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1537                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1538                                     </xref>
1539                                 </featureDetectionMethod>
1540                                 <featureRangeList>
1541                                     <featureRange>
1542                                         <startStatus>
1543                                             <names>
1544                                                 <shortLabel>certain</shortLabel>
1545                                             </names>
1546                                             <xref>
1547                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1548                                                             refTypeAc="MI:0356"/>
1549                                             </xref>
1550                                         </startStatus>
1551                                         <begin position="2096"/>
1552                                         <endStatus>
1553                                             <names>
1554                                                 <shortLabel>certain</shortLabel>
1555                                             </names>
1556                                             <xref>
1557                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1558                                                             refTypeAc="MI:0356"/>
1559                                             </xref>
1560                                         </endStatus>
1561                                         <end position="2096"/>
1562                                     </featureRange>
1563                                 </featureRangeList>
1564                             </feature>
1565                             <feature id="36">
1566                                 <names>
1567                                     <shortLabel>arg2202asp</shortLabel>
1568                                 </names>
1569                                 <featureType>
1570                                     <names>
1571                                         <shortLabel>mutation decreasing</shortLabel>
1572                                         <fullName>mutation decreasing interaction</fullName>
1573                                         <alias>hotspot</alias>
1574                                     </names>
1575                                     <xref>
1576                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
1577                                                     refTypeAc="MI:0356"/>
1578                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1579                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1580                                     </xref>
1581                                 </featureType>
1582                                 <featureDetectionMethod>
1583                                     <names>
1584                                         <shortLabel>mutation analysis</shortLabel>
1585                                         <fullName>mutation analysis</fullName>
1586                                     </names>
1587                                     <xref>
1588                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1589                                                     refTypeAc="MI:0356"/>
1590                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1591                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1592                                     </xref>
1593                                 </featureDetectionMethod>
1594                                 <featureRangeList>
1595                                     <featureRange>
1596                                         <startStatus>
1597                                             <names>
1598                                                 <shortLabel>certain</shortLabel>
1599                                             </names>
1600                                             <xref>
1601                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1602                                                             refTypeAc="MI:0356"/>
1603                                             </xref>
1604                                         </startStatus>
1605                                         <begin position="2202"/>
1606                                         <endStatus>
1607                                             <names>
1608                                                 <shortLabel>certain</shortLabel>
1609                                             </names>
1610                                             <xref>
1611                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1612                                                             refTypeAc="MI:0356"/>
1613                                             </xref>
1614                                         </endStatus>
1615                                         <end position="2202"/>
1616                                     </featureRange>
1617                                 </featureRangeList>
1618                             </feature>
1619                             <feature id="37">
1620                                 <names>
1621                                     <shortLabel>arg2203asp</shortLabel>
1622                                 </names>
1623                                 <featureType>
1624                                     <names>
1625                                         <shortLabel>mutation decreasing</shortLabel>
1626                                         <fullName>mutation decreasing interaction</fullName>
1627                                         <alias>hotspot</alias>
1628                                     </names>
1629                                     <xref>
1630                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
1631                                                     refTypeAc="MI:0356"/>
1632                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1633                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1634                                     </xref>
1635                                 </featureType>
1636                                 <featureDetectionMethod>
1637                                     <names>
1638                                         <shortLabel>mutation analysis</shortLabel>
1639                                         <fullName>mutation analysis</fullName>
1640                                     </names>
1641                                     <xref>
1642                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1643                                                     refTypeAc="MI:0356"/>
1644                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1645                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1646                                     </xref>
1647                                 </featureDetectionMethod>
1648                                 <featureRangeList>
1649                                     <featureRange>
1650                                         <startStatus>
1651                                             <names>
1652                                                 <shortLabel>certain</shortLabel>
1653                                             </names>
1654                                             <xref>
1655                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1656                                                             refTypeAc="MI:0356"/>
1657                                             </xref>
1658                                         </startStatus>
1659                                         <begin position="2203"/>
1660                                         <endStatus>
1661                                             <names>
1662                                                 <shortLabel>certain</shortLabel>
1663                                             </names>
1664                                             <xref>
1665                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1666                                                             refTypeAc="MI:0356"/>
1667                                             </xref>
1668                                         </endStatus>
1669                                         <end position="2203"/>
1670                                     </featureRange>
1671                                 </featureRangeList>
1672                             </feature>
1673                             <feature id="38">
1674                                 <names>
1675                                     <shortLabel>leu2089ala</shortLabel>
1676                                 </names>
1677                                 <featureType>
1678                                     <names>
1679                                         <shortLabel>mutation decreasing</shortLabel>
1680                                         <fullName>mutation decreasing interaction</fullName>
1681                                         <alias>hotspot</alias>
1682                                     </names>
1683                                     <xref>
1684                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity"
1685                                                     refTypeAc="MI:0356"/>
1686                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1687                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1688                                     </xref>
1689                                 </featureType>
1690                                 <featureDetectionMethod>
1691                                     <names>
1692                                         <shortLabel>mutation analysis</shortLabel>
1693                                         <fullName>mutation analysis</fullName>
1694                                     </names>
1695                                     <xref>
1696                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1697                                                     refTypeAc="MI:0356"/>
1698                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1699                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1700                                     </xref>
1701                                 </featureDetectionMethod>
1702                                 <featureRangeList>
1703                                     <featureRange>
1704                                         <startStatus>
1705                                             <names>
1706                                                 <shortLabel>certain</shortLabel>
1707                                             </names>
1708                                             <xref>
1709                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1710                                                             refTypeAc="MI:0356"/>
1711                                             </xref>
1712                                         </startStatus>
1713                                         <begin position="2089"/>
1714                                         <endStatus>
1715                                             <names>
1716                                                 <shortLabel>certain</shortLabel>
1717                                             </names>
1718                                             <xref>
1719                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1720                                                             refTypeAc="MI:0356"/>
1721                                             </xref>
1722                                         </endStatus>
1723                                         <end position="2089"/>
1724                                     </featureRange>
1725                                 </featureRangeList>
1726                             </feature>
1727                         </featureList>
1728                         <hostOrganismList>
1729                             <hostOrganism ncbiTaxId="12081">
1730                                 <names>
1731                                     <shortLabel>pol1m</shortLabel>
1732                                     <fullName>Poliovirus type 1 (strain Mahoney)</fullName>
1733                                 </names>
1734                             </hostOrganism>
1735                         </hostOrganismList>
1736                     </participant>
1737                     <participant id="39">
1738                         <interactorRef>23</interactorRef>
1739                         <biologicalRole>
1740                             <names>
1741                                 <shortLabel>enzyme target</shortLabel>
1742                                 <fullName>enzyme target</fullName>
1743                                 <alias>substrate</alias>
1744                             </names>
1745                             <xref>
1746                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0502" refType="identity"
1747                                             refTypeAc="MI:0356"/>
1748                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1749                                               refTypeAc="MI:0358"/>
1750                             </xref>
1751                         </biologicalRole>
1752                         <experimentalRoleList>
1753                             <experimentalRole>
1754                                 <names>
1755                                     <shortLabel>neutral component</shortLabel>
1756                                     <fullName>neutral component</fullName>
1757                                 </names>
1758                                 <xref>
1759                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity"
1760                                                 refTypeAc="MI:0356"/>
1761                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1762                                                   refTypeAc="MI:0358"/>
1763                                 </xref>
1764                             </experimentalRole>
1765                         </experimentalRoleList>
1766                     </participant>
1767                 </participantList>
1768                 <interactionType>
1769                     <names>
1770                         <shortLabel>elongation</shortLabel>
1771                         <fullName>dna strand elongation</fullName>
1772                         <alias>DNA replication elongation</alias>
1773                     </names>
1774                     <xref>
1775                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0701" refType="identity" refTypeAc="MI:0356"/>
1776                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1777                                       refTypeAc="MI:0358"/>
1778                         <secondaryRef db="go" dbAc="MI:0448" id="GO:0006271" refType="identity" refTypeAc="MI:0356"/>
1779                     </xref>
1780                 </interactionType>
1781                 <attributeList>
1782                     <attribute name="figure legend">Figure 2F and Figure 3</attribute>
1783                     <attribute name="comment">RNA strands bind to form a blunt ended double stranded RNA, authors name
1784                         5.20 RNA
1785                     </attribute>
1786                     <attribute name="kd">0.0</attribute>
1787                 </attributeList>
1788             </interaction>
1789             <interaction id="40">
1790                 <names>
1791                     <shortLabel>polg-polg-1</shortLabel>
1792                     <fullName>Dimerization of Poliovirus type 1 (strain Mahoney)</fullName>
1793                 </names>
1794                 <xref>
1795                     <primaryRef db="intact" dbAc="MI:0469" id="EBI-944619" secondary="polg-polg-1"/>
1796                     <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" refType="function" refTypeAc="MI:0355"
1797                                   secondary="protein homodimerization activ"/>
1798                 </xref>
1799                 <experimentList>
1800                     <experimentRef>41</experimentRef>
1801                 </experimentList>
1802                 <participantList>
1803                     <participant id="42">
1804                         <interactorRef>6</interactorRef>
1805                         <biologicalRole>
1806                             <names>
1807                                 <shortLabel>unspecified role</shortLabel>
1808                                 <fullName>unspecified role</fullName>
1809                             </names>
1810                             <xref>
1811                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity"
1812                                             refTypeAc="MI:0356"/>
1813                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1814                                               refTypeAc="MI:0358"/>
1815                             </xref>
1816                         </biologicalRole>
1817                         <experimentalRoleList>
1818                             <experimentalRole>
1819                                 <names>
1820                                     <shortLabel>neutral component</shortLabel>
1821                                     <fullName>neutral component</fullName>
1822                                 </names>
1823                                 <xref>
1824                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity"
1825                                                 refTypeAc="MI:0356"/>
1826                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1827                                                   refTypeAc="MI:0358"/>
1828                                 </xref>
1829                             </experimentalRole>
1830                         </experimentalRoleList>
1831                         <featureList>
1832                             <feature id="43">
1833                                 <names>
1834                                     <shortLabel>ala1776cys</shortLabel>
1835                                 </names>
1836                                 <featureType>
1837                                     <names>
1838                                         <shortLabel>mutation increasing</shortLabel>
1839                                         <fullName>mutation increasing interaction</fullName>
1840                                     </names>
1841                                     <xref>
1842                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0382" refType="identity"
1843                                                     refTypeAc="MI:0356"/>
1844                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14577292"
1845                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1846                                     </xref>
1847                                 </featureType>
1848                                 <featureDetectionMethod>
1849                                     <names>
1850                                         <shortLabel>mutation analysis</shortLabel>
1851                                         <fullName>mutation analysis</fullName>
1852                                     </names>
1853                                     <xref>
1854                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1855                                                     refTypeAc="MI:0356"/>
1856                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1857                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1858                                     </xref>
1859                                 </featureDetectionMethod>
1860                                 <featureRangeList>
1861                                     <featureRange>
1862                                         <startStatus>
1863                                             <names>
1864                                                 <shortLabel>certain</shortLabel>
1865                                             </names>
1866                                             <xref>
1867                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1868                                                             refTypeAc="MI:0356"/>
1869                                             </xref>
1870                                         </startStatus>
1871                                         <begin position="1776"/>
1872                                         <endStatus>
1873                                             <names>
1874                                                 <shortLabel>certain</shortLabel>
1875                                             </names>
1876                                             <xref>
1877                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1878                                                             refTypeAc="MI:0356"/>
1879                                             </xref>
1880                                         </endStatus>
1881                                         <end position="1776"/>
1882                                     </featureRange>
1883                                 </featureRangeList>
1884                             </feature>
1885                         </featureList>
1886                         <hostOrganismList>
1887                             <hostOrganism ncbiTaxId="12081">
1888                                 <names>
1889                                     <shortLabel>pol1m</shortLabel>
1890                                     <fullName>Poliovirus type 1 (strain Mahoney)</fullName>
1891                                 </names>
1892                             </hostOrganism>
1893                         </hostOrganismList>
1894                     </participant>
1895                     <participant id="44">
1896                         <interactorRef>6</interactorRef>
1897                         <biologicalRole>
1898                             <names>
1899                                 <shortLabel>unspecified role</shortLabel>
1900                                 <fullName>unspecified role</fullName>
1901                             </names>
1902                             <xref>
1903                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity"
1904                                             refTypeAc="MI:0356"/>
1905                                 <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1906                                               refTypeAc="MI:0358"/>
1907                             </xref>
1908                         </biologicalRole>
1909                         <experimentalRoleList>
1910                             <experimentalRole>
1911                                 <names>
1912                                     <shortLabel>neutral component</shortLabel>
1913                                     <fullName>neutral component</fullName>
1914                                 </names>
1915                                 <xref>
1916                                     <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity"
1917                                                 refTypeAc="MI:0356"/>
1918                                     <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1919                                                   refTypeAc="MI:0358"/>
1920                                 </xref>
1921                             </experimentalRole>
1922                         </experimentalRoleList>
1923                         <featureList>
1924                             <feature id="45">
1925                                 <names>
1926                                     <shortLabel>iso2188cys</shortLabel>
1927                                 </names>
1928                                 <featureType>
1929                                     <names>
1930                                         <shortLabel>mutation increasing</shortLabel>
1931                                         <fullName>mutation increasing interaction</fullName>
1932                                     </names>
1933                                     <xref>
1934                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0382" refType="identity"
1935                                                     refTypeAc="MI:0356"/>
1936                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14577292"
1937                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1938                                     </xref>
1939                                 </featureType>
1940                                 <featureDetectionMethod>
1941                                     <names>
1942                                         <shortLabel>mutation analysis</shortLabel>
1943                                         <fullName>mutation analysis</fullName>
1944                                     </names>
1945                                     <xref>
1946                                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity"
1947                                                     refTypeAc="MI:0356"/>
1948                                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292"
1949                                                       refType="primary-reference" refTypeAc="MI:0358"/>
1950                                     </xref>
1951                                 </featureDetectionMethod>
1952                                 <featureRangeList>
1953                                     <featureRange>
1954                                         <startStatus>
1955                                             <names>
1956                                                 <shortLabel>certain</shortLabel>
1957                                             </names>
1958                                             <xref>
1959                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1960                                                             refTypeAc="MI:0356"/>
1961                                             </xref>
1962                                         </startStatus>
1963                                         <begin position="2188"/>
1964                                         <endStatus>
1965                                             <names>
1966                                                 <shortLabel>certain</shortLabel>
1967                                             </names>
1968                                             <xref>
1969                                                 <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity"
1970                                                             refTypeAc="MI:0356"/>
1971                                             </xref>
1972                                         </endStatus>
1973                                         <end position="2188"/>
1974                                     </featureRange>
1975                                 </featureRangeList>
1976                             </feature>
1977                         </featureList>
1978                         <hostOrganismList>
1979                             <hostOrganism ncbiTaxId="12081">
1980                                 <names>
1981                                     <shortLabel>pol1m</shortLabel>
1982                                     <fullName>Poliovirus type 1 (strain Mahoney)</fullName>
1983                                 </names>
1984                             </hostOrganism>
1985                         </hostOrganismList>
1986                     </participant>
1987                 </participantList>
1988                 <interactionType>
1989                     <names>
1990                         <shortLabel>direct interaction</shortLabel>
1991                         <fullName>direct interaction</fullName>
1992                     </names>
1993                     <xref>
1994                         <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
1995                         <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference"
1996                                       refTypeAc="MI:0358"/>
1997                     </xref>
1998                 </interactionType>
1999                 <attributeList>
2000                     <attribute name="figure legend">6E</attribute>
2001                     <attribute name="comment">Under reducing conditions, only protein monomers are observed.</attribute>
2002                     <attribute name="kd">0.0</attribute>
2003                 </attributeList>
2004             </interaction>
2005         </interactionList>
2006     </entry>
2007 </entrySet>
2008 

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Funding for Cytoscape is provided by a federal grant from the U.S. National Institute of General Medical Sciences (NIGMS) of the Na tional Institutes of Health (NIH) under award number GM070743-01. Corporate funding is provided through a contract from Unilever PLC.

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