DomainGraph: Visual Analysis of the Effects of Alternative Splicing on Protein and Domain Interaction Networks

Dorothea Emig¹, Melissa S. Cline², Thomas Lengauer¹, and Mario Albrecht¹

'1 Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, Campus E1.4, 66123 Saarbrücken, Germany '

• 2 Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA

Biological Use Case: Visualize the domain interactions that actually form a protein interaction network. Integrate exon expression data to visualize occurrences of alternative splicing events and the impact on the interactions.

Recipe

Cytoscape version: 2.5, 2.6

Plugins to Load: DomainGraph (http://domaingraph.bioinf.mpi-inf.mpg.de)

GUI steps:

Describe each step (story), the GUI action to take, and probable remarks